![]() ![]() Īn ultrasound and Doppler study of the abdomen would help identify a secondary cause. ![]() Liver cirrhosis and inflammatory liver disease have been associated with secondary polycythemia and increased RBC proliferation. Uric acid levels are often raised due to increased cell proliferation and subsequent turnover. ![]() Renal function abnormalities indicate a higher likelihood of secondary polycythemia. This occurs due to increased transcobalamin III secretion by leukocytes. Raised vitamin B12 levels, often striking, may be observed. Low serum ferritin and low folate levels have been associated more with primary polycythemia. Serum Ferritin, Vitamin B12, and Folate Levels Relevant investigations to detect a possible EPO-secreting tumor Additionally, the potential for progression to leukemia in cases of polycythemia vera also warrants additional management strategies to be implemented. The clinical significance of erythrocytosis, due to any cause, lies in the associated risk of thrombotic events due to hyperviscosity of blood. This condition can be associated with the overproduction of all three cell lines but with a notable predilection towards red blood cells. Often referred to colloquially as simply “polycythemia,” it is an acquired, Philadelphia-chromosome negative, myeloproliferative disorder. Polycythemia vera is a sub-type of polycythemia. The hemoglobin and hematocrit of a menstruating adult female are usually 13 g/dL +/- 2 gm/dl and 40% +/- 6%, respectively. Polycythemia in newborns is defined as a central venous hematocrit over 65% or a hemoglobin value above 22 g/dL. However, as a frame of reference, the hemoglobin and hematocrit of a healthy adult male are 16 g/dL +/- 2 gm/dl and 47% +/- 6%, respectively. The reference ranges for normal hemoglobin levels and hematocrit vary depending on altitude, ethnicity, and country. The standard RBC mass does not usually exceed 36 ml/kg in males and 32 ml/kg in females. In practice, this is reflected by an increase in hemoglobin levels, or hematocrit, over what is considered physiologic for the particular age and gender. Polycythemia, or erythrocytosis, refers to an increase in the absolute red blood cell (RBC) mass in the body. ![]()
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